Publication Title Hyperglycemic Effect on Brain Cholinergic Functions, Oxidative Stress and Protein Expression of Brain Derived Neurotropic Factor (Bdnf) on Cognitive Functions in Streptozotocin Induced-Diabetic Rats Download PDF
Publication Type journal
Publisher Scientific & Academic Publishing
Paper Link doi:10.5923/j.neuroscience.20150401.01
Publication Authors O. A. T. Ebuehi , Dibie D. C.
Year Published 2015-04-01
Abstract Background: Diabetes mellitus (DM) is one of the most severe metabolic disorders in humans characterized by hyperglycemia due to a relative or an absolute lack of insulin or the action of insulin on its target tissue or both. Many neurodegenerative disorders, such as deficits in learning memory and cognition, are associated with diabetes mellitus. Objective: The objective of the present study was to decipher the effect of hyperglycemia on cholinergic functions, oxidative stress and protein expression of brain derived neurotrophic factor (BDNF) in streptozotocin induced- diabetic rats. Methods: Streptozotocin (STZ)-induced diabetic rats were used for the study. Twelve male Sprague-Dawley rats (130-150g) each were divided into 2equal groups with six rats in each group (diabetic and control). The rats were sacrificed and biochemical parameters, such as blood glucose, C-peptide, total protein, acetyl choline levels, acetyl cholinesterase activity and antioxidant status were determined. The BDNF protein expression and learning, memory and cognitive functions in rats were also determined. Results: The results obtained showed that diabetic rats exhibited decreased acetylcholine level and also an alteration (down regulation) of the expressed BDNF of STZ-induced diabetic rats compared with the control. The diabetic rats also exhibited significantly decreased plasma C-peptide and total protein levels, as well as increased oxidative stress. Conclusions: Data of the study indicate that the streptozotocin induced diabetic rats had increased oxidative stress, decreased acetylcholine levels and down regulation of BDNF protein expression, thereby impairing memory, learning, and cognitive functions.
Publication Title Caffeine as a Psychoactive Drug: The Genetic Basis for Differences in Response by Caffeine Sensitive and Caffeine Tolerant Individuals-A Mini Review Download PDF
Publication Type journal
Publisher Creative Commons.
Paper Link https://jphtr.com/index.php/journal
Publication Authors DC Dibie, TO Njideaka, OB Onyeukwu
Year Published 2023-10-11
Abstract Background: Caffeine (1, 3, 7–trimethylxanthine) is a chemical compound that has a psychoactive effect on the central nervous system of the brain. It is obtained from the fruits, leaves and seeds of different plant species. Objectives: It is widely consumed by millions of people. In addition to other sources, consumption of coffee and energy drink are the major means through which caffeine enters the body. Methods: While caffeine is well tolerated by some individuals, it also causes some serious pharmacological health issues such as, difficulty in breathing, cardiac conduction anomaly, insomnia, headaches, anxiety, gut dysfunction, diuresis, increased heart rate, increased mental alertness and motor activity. Results: It was discovered that there is a genetic basis for these different responses or reactions to caffeine. Conclusions: This paper, therefore, reviews the genetic basis for the different reactions to caffeine and suggested recommendations for proper administration of caffeine to consumers as well as an area for further scientific research.
Publication Title Hibiscus sabdariffa - uses, nutritional and therapeutic benefits - A review Download PDF
Publication Type journal
Publisher Creative Commons.
Paper Link https://doi.org/10.31248/JBBD2023.178
Publication Authors Onyeka Benjamin Onyeukwu* , Dumebi Chidinma Dibie and Ogochukwu Tracy Njideaka
Year Published 2023-04-01
Abstract Hibiscus sabdariffa is a shrub that belongs to the family Malvacea. Over 200 different species of Hibiscus exist worldwide. Hisbiscus sabdariffa has been noted to have a high nutritional potential, particularly in the leaves, calyces, and seeds. The Roselle calyx, which is used to make a variety of beverages, has been said to contain a significant amount of vitamins, minerals, flavonoids, protein, lipids, carbs, and other nutrients. There are reports on the plants' antioxidant, antihypertensive, hepatoprotective, nutritive, and antihyperlipemic qualities. Reviewing the uses, the nutritional worth and therapeutic benefits of Hibiscus sabdariffa is the goal of this paper.