Dr. ADU MATTHEW ETURHOBORE
Publication Title Distribution of ABO and Rhesus Blood Groups in HIV Seropositive Patients in Agbor, Delta State Nigeria
Publication Type Published Research
Publisher Michael Joanna PublicationsMichael Joanna Publications
Publication Authors Adu E.M, Ezie E, Onyekpe J.O and Oseodion J. A
Year Published 7-08
Abstract Background: The ABO blood group system discovered by Karl Landsteiner has been found to be associated with various diseases including Human Immunodeficiency Virus (HIV). Aim: To determine the distribution of ABO and rhesus blood groups among seropositive patients. Methods: ABO and Rhesus blood groups of 376 seropositives individuals attending the Antiretroviral Therapy Centre (ART) Agbor, Delta state between January and April 2014 were used for this study. The cell grouping using tile method was applied for the survey. Results: Out of the 376 volunteers use for this study, 282 (75%) where females and 94 (25%) were males. Blood group O has the highest prevalence, 204 (54.2%), followed by blood group A, 104 (27.7%), and B has 58(15.4%). Blood group AB has the least prevalence, 10(2.7%). Conclusion: This study re-affirms that blood group O is the most common blood group in this locality.Background: The ABO blood group system discovered by Karl Landsteiner has been found to be associated with various diseases including Human Immunodeficiency Virus (HIV). Aim: To determine the distribution of ABO and rhesus blood groups among seropositive patients. Methods: ABO and Rhesus blood groups of 376 seropositives individuals attending the Antiretroviral Therapy Centre (ART) Agbor, Delta state between January and April 2014 were used for this study. The cell grouping using tile method was applied for the survey. Results: Out of the 376 volunteers use for this study, 282 (75%) where females and 94 (25%) were males. Blood group O has the highest prevalence, 204 (54.2%), followed by blood group A, 104 (27.7%), and B has 58(15.4%). Blood group AB has the least prevalence, 10(2.7%). Conclusion: This study re-affirms that blood group O is the most common blood group in this locality.
Publication Title Comparative Analysis of the Properties of Acid-Base Indicator of Rose (Rosa setigera), Allamanda (Allamanda cathartica), and Hibiscus (Hibiscus rosa-sinensis) FlowersComparative Analysis of the Properties of Acid-Base Indicator of Rose (Rosa setigera), Allamanda (Allamanda cathartica), and Hibiscus (Hibiscus rosa-sinensis) Flowers
Publication Type journal
Publisher Hindawi Publishing Corporation
Publication Authors STANLEY I. R. OKODUWA, LOVINA O. MBORA,MATTHEW E. ADU AND AMEH A. ADEYI
Year Published 3-05
Abstract The need to develop effective alternative for synthetic indicators is the demand of present-day chemistry.The acid-base indicator
properties of Rose (Rosa setigera), Allamanda (Allamanda cathartica), andHibiscus (Hibiscus rosa-sinensis) flowers were examined.
Colour pigments were extracted from the flowers via cold and solvent extraction using soxhlet extractor. The pH value of the
extracts with wavelengths of absorption was determined using ultraviolet spectrophotometer. From the results obtained, all the
extracts exhibited sharp contrast between their colours in acid and base.Their pH was found to be 5.5 for cold extract of Rose and
5.6 for solvent extraction, 5.24 for cold extract of a Hibiscus and 6.52 for solvent extraction, 5.35 for cold extract of Allamanda, and
5.45 for solvent extraction. The maximum wavelengths of absorption obtained for all the extract fall within the visible region of
electromagnetic spectrum. These values are almost similar to that obtained from synthetic indicators. It is on these bases that we
concluded that natural indicators could be an excellent replacement for synthetic indicators since they are cheap, readily available,
simple to extract, not toxic, user and environmentally friendly.
Publication Title Comparative Analysis of the Properties of Acid-Base Indicator of Rose (Rosa setigera), Allamanda (Allamanda cathartica), and Hibiscus (Hibiscus rosa-sinensis) FlowersComparative Analysis of the Properties of Acid-Base Indicator of Rose (Rosa setigera), Allamanda (Allamanda cathartica), and Hibiscus (Hibiscus rosa-sinensis) Flowers
Publication Type journal
Publisher Hindawi Publishing Corporation
Publication Authors STANLEY I. R. OKODUWA, LOVINA O. MBORA,MATTHEW E. ADU AND AMEH A. ADEYI
Year Published 3-05
Abstract The need to develop effective alternative for synthetic indicators is the demand of present-day chemistry.The acid-base indicator
properties of Rose (Rosa setigera), Allamanda (Allamanda cathartica), andHibiscus (Hibiscus rosa-sinensis) flowers were examined.
Colour pigments were extracted from the flowers via cold and solvent extraction using soxhlet extractor. The pH value of the
extracts with wavelengths of absorption was determined using ultraviolet spectrophotometer. From the results obtained, all the
extracts exhibited sharp contrast between their colours in acid and base.Their pH was found to be 5.5 for cold extract of Rose and
5.6 for solvent extraction, 5.24 for cold extract of a Hibiscus and 6.52 for solvent extraction, 5.35 for cold extract of Allamanda, and
5.45 for solvent extraction. The maximum wavelengths of absorption obtained for all the extract fall within the visible region of
electromagnetic spectrum. These values are almost similar to that obtained from synthetic indicators. It is on these bases that we
concluded that natural indicators could be an excellent replacement for synthetic indicators since they are cheap, readily available,
simple to extract, not toxic, user and environmentally friendly.
Publication Title Seroprevalence of Syphilis in Apparently healthy Students from a Tertiary Institution in Benin City, Nigeria
Publication Type journal
Publisher
Publication Authors ENDURANCE ANTHONY OPHORI, ATANUNU OVIE, EJIRO JESICA JOHANNY AND MATTHEW ADU
Year Published 8-23
Abstract The seroprevalence of syphilis in students from a tertiary institution in Benin City, Nige-
ria was investigated. Venous blood samples (5 mL) were collected from 214 apparently healthy students
aged 19–38 years (118 males and 96 females) between February and October 2009 and the serostatus of
syphilis determined qualitatively using the rapid plasma reagin test. Seropositive sera were confirmed
using the Treponema pallidum hemagglutination test. The total seropositivity for syphilis was 15.4z,
with a prevalence in males and females of 18.6 and 11.4z, respectively. This difference was statistically
significant ( P º 0.05). The highest prevalence was found for the 24–28-year-old age group, while the
lowest prevalence was found for the 19–23-year-old age group, where no female tested positive. The
results of this study show that the prevalence of syphilis infection among students in Benin City was high
and is a public health concern. All persons, including voluntary blood donors, patients with sexually
transmitted diseases, or those attending for routine medical checkups, should therefore be thoroughly
screened for syphilis infection
Publication Title Serum Lipid Profile Abnormalities among patients with nephrotic syndrome.
Publication Type journal
Publisher Michael Joanna PublicationsMichael Joanna Publications
Publication Authors ADU EM
Year Published 2-22
Abstract Background: Nephrotic syndrome is a multifactorial clinical condition
characterized by increased glomerular permeability with consequent
massive proteinuria. Hyperlipidaemia has been found to be one of the
cardinal manifestations of nephrotic syndrome. Aim: The present study
was conducted to determine the lipid profile and cardiovascular risk of
nephrotics in this locality. Methods: Serum total cholesterol (TC),
triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein
(LDL), very low density lipoprotein (VLDL) as well as atherogenic index
(AI), coronary risk index (CRI) and non-HDL cholesterol were determined
in ninety-six subjects. Forty-eight were nephrotic patients while others
were apparently healthy individuals used as controls. Result: TC, TG, and
LDL-C of nephrotics was observed to be significantly higher (P<0>0.05). HDL-C of nephrotics
was observed to be significantly lower (P<0.05) when compared with
control subjects. Conclusion: The result indicates apparent lipid
derangement in nephrotic syndrome which may lead to cardiovascular
disease. We therefore recommend that full lipid panel should be included
in the investigation of suspected nephrotics to complement early diagnosis
of the syndrome and to prevent further complications that could arise from
the syndrome.
Publication Title SERUM LIPID ABNORMALITIES IN TYPE 2 DIABETES MELLITUS
Publication Type journal
Publisher Society for Cellular Pathology Scientists of Nigeria
Publication Authors ADU EM
Year Published 3-13
Abstract Aim: Diabetes mellitus is a clinical syndrome characterized by hyperglycemia due to
absolute or relative deficiency of insulin. The present study was conducted to
determine the lipid profile of diabetes in Delta State.
Methods: Serum total cholesterol (TC), triglycerides (TG), high density lipoprotein
(HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) as well as
Body mass index (BMI) were determined in two hundred subjects. One hundred were
diabetic and the other one hundred were apparently healthy individuals used as
controls.
Results: The TC, TG, LDL-C, VLDL-C as well as BMI of diabetes were observed to
be significantly high (P<0.05) when compared with control subjects. HDL-C in
diabetes was observed to be significantly low (P<0.05) when compared with control
subjects.
Conclusion: The result indicates dyslipidemia in diabetes. Adequate and proper
management of diabetes to reduce dyslipidemia and further complications are
therefore recommended.
Publication Title Serum lipids and Vitamin C levels of male cigarette smokers in Asaba, Delta State, Nigeria
Publication Type journal
Publisher University of Babylon
Publication Authors Adikema N.A. and Adu, E.M
Year Published 1-17
Abstract Two hundred male subjects were selected randomly in parts of Delta State out of which 100 were
cigarette smokers and another 100 non-smokers which served as control. Serum ascorbic acid level
(AA), High Density Lipoprotein Cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG), low
density lipoprotein cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL- C) were
determined in all the samples taken from the subjects. Results were compared using the T-test at
p<0.001. The serum level of vitamin C in smokers (0.81 ± 0.06 mg/dl) was found to be significantly
lower than for non-smokers (1.10 ± 0.05 mg/dl); HDL-C level in smokers (30.82 ± 3..08 mg/dl) was
found to be significantly decreased in smokers as against non-smokers (47.48 ± 2.85mg/dl); TC level in
smokers (274.84 ± 11.16mg/dl) was significantly higher than non-smokers (166.68 ± 6.78mg/dl); TG
level in smokers (250.38 ± 6.79mg/dl) was significantly higher than in non-smokers (149.39 ±
4.15mg/dl); LDL-C level in smokers (194.02 ± 11.13mg/dl) was significantly higher than in nonsmokers (88.99 ± 7.56mg/dl); VLDL- C level of smokers (50.07 ± 1.35 mg/dl) was significantly
increased in smokers as against non-smokers (29.86 ± 0.82mg/dl). The data obtained are useful for the
control of cigarette smoking which causes heart diseases and reduction in anti-oxidation capacity of the
body
Publication Title Serum Testosterone level in Nigerian Marijuana and Cigarette Smokers.
Publication Type journal
Publisher Society for Cellular Pathology Scientists of Nigeria
Paper Link www.ajcpath.comwww.ajcpath.com
Publication Authors Adu E.M, Popoola O. A and Adikema N.A
Year Published 3-31
Abstract Aim: To evaluate the effects of marijuana and cigarette smoke on serum
testosterone level in male marijuana and cigarette smokers.
Methods: Testosterone was estimated using enzyme immunoassay on micro
plate format in 30 marijuana smokers, 15 cigarette smokers and 25 sex, age
matched non-smokers as controls. Body mass index (BMI) of all subjects
was also calculated.
Results: There was a significant decrease (P<0>0.05)
when compared with cigarette smokers (5.4±1.5ng/ml). A significant
difference (P<0.05) was observed when cigarette smokers were compared
with non-smokers. The BMI of marijuana smokers was significantly higher
when compared with cigarette smokers and non-smokers but no significant
difference was observed between cigarette smokers and non-smokers.
Conclusion: These differences are attributed to the psychoactive chemical
and pro-oxidants as well as oxidants present in marijuana and cigarette
smoke which alter the hypothalamic-pituitary-gonadal integrity. We
therefore recommend that stringent measures should be put in place to curb
the indiscriminate use of the substances and also smoking history should be
considered in the diagnosis of infertility in males.
Publication Title Prevalence of Haemoglobin Variants among the Ika ethnic Nationality of Delta State.
Publication Type Published Research
Publisher Michael Joanna PublicationsMichael Joanna Publications
Publication Authors Adu E.M, Isibor C.N and Ezie E
Year Published 7-26
Abstract Background: Haemoglobin genotype is an important blood
component that determines haemoglobinopathies. Distribution
of haemoglobin variants was investigated among the Ika ethnic
nationality of Delta State, Nigeria. Aim: The present study was
conducted to determine the prevalence of haemoglobin variants
and also to provide information for instituting genetic counseling
services to reduce haemoglobinopathies between couples.
Methods: A total of 600 subjects were screened for
haemoglobin genotypes using paper electrophoresis. Results:
The prevalence of HbAA, HbAS, HbAC and HbSS were 78%,
19.5%, 0.5% and 2% respectively. There was no relationship
(P?0.05) between sex and haemoglobin variants. There was a
low prevalence of abnormal haemoglobin variants observed
which is consistent with previous studies. Conclusion: The
sickle cell trait (HbAS) is the largest variant in this population;
we therefore advocate mandatory haemglobin genotype
screening for all intending couples in order to reduce the
sickling gene pool.Background: Haemoglobin genotype is an important blood
component that determines haemoglobinopathies. Distribution
of haemoglobin variants was investigated among the Ika ethnic
nationality of Delta State, Nigeria. Aim: The present study was
conducted to determine the prevalence of haemoglobin variants
and also to provide information for instituting genetic counseling
services to reduce haemoglobinopathies between couples.
Methods: A total of 600 subjects were screened for
haemoglobin genotypes using paper electrophoresis. Results:
The prevalence of HbAA, HbAS, HbAC and HbSS were 78%,
19.5%, 0.5% and 2% respectively. There was no relationship
(P?0.05) between sex and haemoglobin variants. There was a
low prevalence of abnormal haemoglobin variants observed
which is consistent with previous studies. Conclusion: The
sickle cell trait (HbAS) is the largest variant in this population;
we therefore advocate mandatory haemglobin genotype
screening for all intending couples in order to reduce the
sickling gene pool.
Publication Title Evaluation of Serum Lipid in Hypertensives in Niger Delta, Nigeria
Publication Type Published Research
Publisher Michael Joanna PublicationsMichael Joanna Publications
Publication Authors 28. Bini N.E, Adu E.M, Inedi A.F, Dike M, Iyekekpolor J and Amag R.U
Year Published 0-23
Abstract Background: H ypertension is a health challenge in both develo ping and developed natio ns. It is an important public health challenge worldwide because of its high frequency and concomitant risks of cardiovascular and kidney dis ease. Aim: The aim of the study was to exam ine lipid profile of hypertensives and compare with normotensive ind ividuals. Methods: The volunteers are patients attending the general ou t-patient clinics in health facilities in Niger-Delta region South-South Nigeria. Venous blood was collected from 1428 volunteers, allowed to clot and separated into serum. Serum total cholesterol, triglycerides, HDL-cholesterol was estimated by standard methods while LDL-C and VLDL-C were calculated. Results: Our results show increase levels of total cholesterol, tri glyceride, LDL-C and VLDL-C in hypertensives than normotensives while HDL-C is increased in normotensives than in hypertensives. Conclusion: We affirm the lipid pattern of hypertensives and normotensives and incriminated dyslipidaemia as a cause o f arterial hypertension. W e therefore advocate routine lipid profile in the r etinue of test panel for h ypertensives to nip any complication that may arise in the bud.
Publication Title Evaluation of serum proteins in pulmonary tuberculosis.
Publication Type Published Research
Publisher Society for Cellular Pathology Scientists of Nigeria
Publication Authors 26. Jemikalajah D.J, Okogun G.R.A, Adu M.E and Okolie G.C
Year Published 2-05
Abstract Aim: Tuberculosis (TB) remains a major public health problem throughout the
world, especially in developing countries with its attendant mortality and morbidity.
Proteins in plasma or serum are readily accessible and can be analyzed directly to
produce diagnostic information on disease states in patients.
Methods: 5ml of venous blood was collected from One hundred (100) volunteers
which comprised fifty (50) pulmonary tuberculosis patients and fifty (50) age – sex
matched apparently healthy subjects as controls. The levels of total proteins,
albumin, globulins and albumin/globulin ratio were determined in pulmonary
tuberculosis patients.
Results: Our results show significantly increased total protein, albumin and
globulins in pulmonary tuberculosis patients when compared with controls but no
significant difference was observed in the albumin/globulin ratio. There was gender
difference in globulin levels.
Conclusion: The study has heightened the imperative of serum proteins assay in the
management of pulmonary tuberculosis.
Publication Title Prevalence of Mycobacterium tuberculosis (MTB) among Human Immunodeficiency virus patients at ART Centre Agbor
Publication Type Published Research
Publisher Society for Cellular Pathology Scientists of Nigeria
Publication Authors Adu M.E, Ezie E, Isibor C. N and Jemikalajah D.J
Year Published 2-07
Abstract Aim: The prevalence of pulmonary tuberculosis (PTB) in Human immunodeficiency virus (HIV)/Acquired immunodeficiency syndrome (AIDS) patients is a dual epidemic problem of major concern worldwide especially in Africa where there is upsurge of the disease. This study is set to determine the prevalence of PTB among HIV patients.
Methods: A total of 489 patients were recruited into the study, 173(35.4%) were males, while 316 (64.6%) were females between January 2012 and December 2013. HIV status and Mycobacterium tuberculosis were determined using WHO systems two and Ziehl Neelsen (ZN) staining technique respectively.
Results: Prevalence of 10.6%, 79.6% and 9.8% was obtained for HIV/PTB co infection, HIV and PTB respectively. A prevalence of 5.1% recorded for HIV/PTB co infection is highest among age group 31-45years, followed by 2.7% and 1.6% in the age groups 16-30 and 46-60years respectively. The lowest prevalence of 0.2% each was observed in the age groups 61-75 and 76-90 years.
Conclusion: There is need for more advocacy and proper monitoring of infected patients to check the spread of HIV infections especially in a depressed economy like Nigeria in order to further reduce cases of PTB.
Publication Title ). Effect of Oral Vitamin E on serum Lipid Profile of Apparently Healthy Nigerians in Benin City
Publication Type Published Research
Publisher Tropical Journal of Pharmaceutical Research
Paper Link http://dx.doi.org/10.4314/tjpr.v14i6.19
Publication Authors 24. Okosun R.E and Adu M.E
Year Published 4-26
Abstract Purpose: To investigate the effect of oral vitamin E on serum lipid profile of Apparently Healthy
Nigerians in Benin City
Methods: Fifty eight apparently healthy non-smoking males aged 30 - 59 years were randomly selected
from Benin metropolis and were divided in three groups. The effect of oral vitamin E (a potent
antioxidant) supplementation in various dosages 100 mg/day,200 mg/day and 400 mg/day for 21 days
on Total cholesterol, Triglycerides, High Density Lipoprotein, Low Density Lipoprotein and Very low
Density Lipoprotein was examined.
Results: The serum total cholesterol, triglycerides, low density lipoprotein and very low density
lipoprotein of the subjects showed a decrease which was not statistically significant (p > 0.05) after
treatment with various doses of oral vitamin E.
Conclusion: The effect of oral vitamin E on blood lipids is not significant when administered alone to
healthy male subjects. This may be due to the function of ?- tocopherol (vitamin E) as a pro-oxidant in
the formation of lipid radical via ?- tocopherol mediated pathway.
Publication Title Evaluation of Serum Proteins in some immune- compromised patients in Auchi, Edo State
Publication Type Published Research
Publisher Society for Cellular Pathology Scientists of Nigeria
Publication Authors 23. Okogun G.R.A, Jemikalajah D.J, Adu M.E and Saliu R
Year Published 2-15
Abstract Aim: Immuno compromised state is a condition of alteration in the immune status of an individual, thereby promoting progression of a disease. This work investigated serum proteins in immuno compromised individuals.
Methods: 5ml venous blood was collected from 120 volunteers which comprised 20 tuberculosis patients, 40 Human immunodeficiency virus patients, 40 pregnant women and 20 age –sex matched apparently healthy individual as controls in Central Hospital Auchi, Edo State. Standard colorimetric method was used to determine the serum total protein, albumin, and globulin as well as albumin/globulin ratio.
Results: A significant increase in total proteins, albumin, and globulins as well as albumin/globulin ratio of Tuberculosis and HIV patients but decrease in pregnant women when compared with control subjects was observed.
Conclusion: Serum protein is a significant diagnostic index in the management of immune-compromised patients.
Publication Title Assessment of cardiovascular Risk indices in Type 2 Diabetes Mellitus
Publication Type Published Research
Publisher Tropical Medicine & Surgery
Paper Link doi:10.4172/2329-9088.1000184
Publication Authors 22. Adu M.E, Ukwamedu H.A and Oghagbon E.S
Year Published 4-30
Abstract Background: Dyslipidemia a common feature of diabetes mellitus leads to cardiovascular complications. These
complications are not detected early enough due to absence of cheap and routine biomarker.
Aim: Therefore, the aim of this study is to assess the cardiovascular risk indices of diabetes mellitus individuals
using Atherogenic coefficient (Ac), Cardiac Risk Ratio (CRR), Atherogenic index of plasma (AIP) and Non- HDL –
cholesterol (surrogate marker for apolipoprotein B) in this locality.
Methods: Serum Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C), Low
Density Lipoprotein-Cholesterol (LDL-C), Very Low Density Lipoprotein-Cholesterol (VLDL-C) as well as
cardiovascular risk indices (Cardiac Risk Ratio (CRR), atherogenic coefficient (Ac), atherogenic index of plasma
(AIP) and Non-HDL cholesterol) were assessed.
Results: The TC,TG,LDL-C,VLDL-C as well as all the cardiometabolic risk indices of diabetes were observed to
be significantly high (P<0.05) when compared with control subjects. HDL-C in diabetes was observed to be
significantly low (P<0.05) when compared with control subjects.
Conclusion: The results indicates greater propensity of diabetes to cardiovascular complications. We therefore
advocate routine use of these indices as part of lipid profile in order to nip any cardiovascular complication early
enough.Background: Dyslipidemia a common feature of diabetes mellitus leads to cardiovascular complications. These
complications are not detected early enough due to absence of cheap and routine biomarker.
Aim: Therefore, the aim of this study is to assess the cardiovascular risk indices of diabetes mellitus individuals
using Atherogenic coefficient (Ac), Cardiac Risk Ratio (CRR), Atherogenic index of plasma (AIP) and Non- HDL –
cholesterol (surrogate marker for apolipoprotein B) in this locality.
Methods: Serum Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C), Low
Density Lipoprotein-Cholesterol (LDL-C), Very Low Density Lipoprotein-Cholesterol (VLDL-C) as well as
cardiovascular risk indices (Cardiac Risk Ratio (CRR), atherogenic coefficient (Ac), atherogenic index of plasma
(AIP) and Non-HDL cholesterol) were assessed.
Results: The TC,TG,LDL-C,VLDL-C as well as all the cardiometabolic risk indices of diabetes were observed to
be significantly high (P<0.05) when compared with control subjects. HDL-C in diabetes was observed to be
significantly low (P<0.05) when compared with control subjects.
Conclusion: The results indicates greater propensity of diabetes to cardiovascular complications. We therefore
advocate routine use of these indices as part of lipid profile in order to nip any cardiovascular complication early
enough.
Publication Title Assessment of Serum Proteins in Human Immunodeficiency Virus Patients in Auchi, Edo State
Publication Type Published Research
Publisher Society for Cellular Pathology Scientists of Nigeria
Publication Authors 20. Jemikalajah D.J and Adu M.E
Year Published 2-20
Abstract Aim: Human immunodeficiency virus infection has become pandemic in Nigeria
and affects the immune system. Proteins are major components of the immune
system and their evaluation gives diagnostic information. We sought to examine
serum proteins of HIV seropositve patients in Auchi, Edo State.
Methods: Sixty patients comprising of 40 HIV seropositive and 20 HIV
seronegative individuals attending Central Hospital, Auchi, Nigeria were randomly
recruited. Serum total protein, albumin and globulin were estimated.
Results: Serum total proteins, albumin and globulin were significantly increased in
HIV seropositive individuals while albumin: globulin ratio was significantly
decreased when compared with HIV seronegative individuals. There was no
significant difference observed in terms of gender.
Conclusion: Serum proteins increase with HIV progression and therefore can be
used as a biomarker in the assessment of the progress of the infection.Aim: Human immunodeficiency virus infection has become pandemic in Nigeria
and affects the immune system. Proteins are major components of the immune
system and their evaluation gives diagnostic information. We sought to examine
serum proteins of HIV seropositve patients in Auchi, Edo State.
Methods: Sixty patients comprising of 40 HIV seropositive and 20 HIV
seronegative individuals attending Central Hospital, Auchi, Nigeria were randomly
recruited. Serum total protein, albumin and globulin were estimated.
Results: Serum total proteins, albumin and globulin were significantly increased in
HIV seropositive individuals while albumin: globulin ratio was significantly
decreased when compared with HIV seronegative individuals. There was no
significant difference observed in terms of gender.
Conclusion: Serum proteins increase with HIV progression and therefore can be
used as a biomarker in the assessment of the progress of the infection.
Publication Title Evaluation of some Biochemical parameters among Sickle cells patients in steady state
Publication Type Published Research
Publisher Department of Medical Laboratory Science, Bayero University Kano
Publication Authors 12. Jemikalajah DJ, Adu ME and Digban AK
Year Published 3-15
Abstract Background: Sickle cell disease (SCD) is an autosomal inherited disorder of
haemoglobin caused by a substitution of thymidine for adenine (GAG-GTG) of the ?-
chain that results in the amino acid valine instead of glutamic acid. This congenital
haemoglobin mutation results in alteration in the biochemical parameters of these
individuals.
Aim: Our aim is to assess some biochemical parameters (Glucose, Total protein,
Albumin, Globulin and Creatinine) of sickle cell patients.
Methods: A total of one hundred and ten (110) subjects were recruited for this
studywhich consists of fifty (50) sickle cell subjects and sixty (60) apparently healthy
subjects which served as control. Out of the total fifty subjects 28 were males and 22 were
females. The control subjects comprised of 21 males and 39 females. Blood samples were
analyzed using standardspectrophotomeric methods.
Results: All the estimated parameters were significantly higher in sickle cell patients
except creatinine which was statistically lowered when compared to controls.
Conclusion: Therefore sickle cell patients have altered biochemical parameters which
need to be assessed routinely to prevent morbidity and mortality.